The used AB SCIEX 6500+ LC-MS/MS system is a high-performance, industry-leading mass spectrometer, available in both Triple Quad 6500+ and QTRAP 6500+ configurations. It is designed for highly sensitive, rapid, and robust quantitative and qualitative analysis of complex samples when coupled with Liquid Chromatography (LC). Its core strength lies in the revolutionary IonDrive technology, which maximizes ion generation, transmission, and detection. This includes the redesigned IonDrive Turbo V source for higher ion yields, the IonDrive QJet ion guide for efficient focusing, and the IonDrive High Energy Detector+ for unprecedented signal-to-noise ratios and sub-femtogram limits of detection (LOD). These enhancements make it a cost-effective yet powerful solution for laboratories requiring top-tier trace-level quantification in demanding matrices, offering reliability and performance comparable to new instruments at a fraction of the cost.
Performance and throughput are key advantages of the 6500+ platform. It boasts a linear dynamic range of up to six orders of magnitude, allowing simultaneous quantification across vast concentration spectra without dilution. With scan speeds up to 20,000 Da/s and polarity switching as fast as 5 milliseconds, it perfectly matches modern UHPLC gradients for high-sample-throughput workflows. The QTRAP 6500+ configuration uniquely offers hybrid triple quadrupole/linear ion trap capabilities, enabling high-sensitivity quantitative MRM transitions and confirmatory qualitative scans (e.g., enhanced product ion scans) in a single injection. This boosts productivity in metabolite ID, impurity profiling, and forensic toxicology. The standard IonDrive Turbo V source supports both ESI and APCI probes, accommodating a wide range of compound polarities (mass range 5–2000 m/z). Optional SelexION+ DMS further improves selectivity by separating isobaric interferences based on ion size and shape, reducing background noise in complex biological or environmental extracts without sacrificing sensitivity.
Versatile applications span multiple industries. In pharmaceutical R&D, it is a gold standard for DMPK studies, bioanalysis of drug candidates/metabolites in biological fluids, and ultra-trace quantification of impurities or HCPs. Clinical research labs use it for TDM, neonatal screening (e.g., amino acids, acylcarnitines), and biomarker validation. It excels in food safety and environmental testing for multi-residue pesticide/veterinary drug analysis, mycotoxin detection, and monitoring contaminants like PFAS in water/soil. Academic and biotech sectors employ it for metabolomics, proteomics, and complex matrix analysis. Control and data analysis are managed via intuitive Analyst software or the advanced SCIEX OS platform, both offering compliance-ready features (audit trails, electronic signatures, user management) to satisfy FDA 21 CFR Part 11 and GMP/GLP requirements. This used system, often paired with a compatible UHPLC, delivers exceptional value, empowering labs to achieve reliable, publication-quality results efficiently.
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Item
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Specification
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System Type
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Triple Quad 6500+ / QTRAP 6500+ LC-MS/MS
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Mass Range
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5 – 2,000 m/z (Triple Quad); 50 – 2,000 m/z (Linear Ion Trap)
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Sensitivity (ESI+)
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1 pg Reserpine, S/N ≥ 500,000:1 (MRM mode)
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Scan Speed
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Up to 20,000 Da/s
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Polarity Switching
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≤ 5 ms (MRM mode)
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Dynamic Range
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Up to 6 orders of magnitude
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Ion Source
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IonDrive Turbo V (Standard ESI/APCI); Optional APPI, DuoSpray, NanoSpray
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Detector
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IonDrive High Energy Detector+ (HED+)
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Ion Guide
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IonDrive QJet (Dual-stage)
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Optional Tech
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SelexION+ Differential Ion Mobility Spectrometry (DMS)
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Vacuum System
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Rotary vane pump + Turbomolecular pump
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Data System
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Analyst Software or SCIEX OS (supports 21 CFR Part 11)
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Power
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100-240 V, 50/60 Hz, ~2.5 kW
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Dimensions (W×D×H)
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Approx. 90 × 90 × 120 cm
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Weight
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Approx. 250 kg
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Key Applications
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DMPK, Bioanalysis, Clinical TDM, Food/Environmental Residues, Metabolomics
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