The used AB SCIEX QTRAP 5500 LC-MS/MS system is a robust, field-proven hybrid mass spectrometer that masterfully combines the quantitative power of a triple quadrupole with the qualitative capabilities of a linear ion trap. Designed for laboratories requiring high sensitivity and throughput on a budget, this platform utilizes the advanced Turbo V ion source (supporting ESI and APCI) alongside the QJet-2 ion guide and AcQuRate pulse-counting detector. This configuration delivers exceptional ion transmission efficiency and a linear dynamic range of over six orders of magnitude. Its hallmark feature is the MRM-IDA-EPI workflow: in a single injection, the system can perform high-sensitivity Multiple Reaction Monitoring (MRM) quantification while automatically triggering Enhanced Product Ion (EPI) scans for structural confirmation, effectively eliminating false positives in complex matrices.
Engineered for speed and versatility, the QTRAP 5500 achieves scan speeds of up to 20,000 Da/s in the ion trap and 12,000 Da/s in the quadrupole, with polarity switching as fast as 5 milliseconds. This performance makes it ideally suited for fast UHPLC gradients and high-throughput screening. The system supports a variety of advanced scan modes, including MRM3 (MS/MS/MS) for enhanced selectivity in dirty samples and comprehensive qualitative workflows. Optional integration with SelexION Differential Ion Mobility Spectrometry (DMS) adds another dimension of separation, resolving isobaric interferences based on ion size and shape without compromising quantitative sensitivity. Controlled by Analyst software or the SCIEX OS platform, the system offers scheduling algorithms for MRM and full compliance features (audit trails, electronic signatures) to meet FDA 21 CFR Part 11 and GMP/GLP requirements.
This refurbished system serves as a workhorse across diverse industries. In pharmaceutical R&D, it is a gold standard for DMPK studies, bioanalysis of drug candidates in plasma/urine, and biomarker validation. Clinical and forensic labs rely on it for therapeutic drug monitoring (TDM), neonatal screening panels (amino acids, acylcarnitines), and broad-spectrum toxicology. It is equally powerful in food safety and environmental testing for the multi-residue analysis of pesticides, veterinary drugs, mycotoxins, and persistent contaminants like PFAS. Opting for a used QTRAP 5500 offers laboratories access to premium, publication-grade mass spectrometry performance at a fraction of the cost of a new instrument, providing an ideal balance of reliability, versatility, and value for high-demand analytical workflows.
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Item
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Specification
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System Type
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Hybrid Triple Quadrupole / Linear Ion Trap (QTRAP 5500)
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Mass Range
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5 – 1,250 m/z (standard); optional 5 – 2,000 m/z
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Sensitivity (MRM)
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1 pg Reserpine, S/N ≥ 500,000:1 (typical, column injection)
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Scan Speed
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Up to 12,000 Da/s (Q1); Up to 20,000 Da/s (Ion Trap)
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Polarity Switching
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≤ 5 ms
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Dynamic Range
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> 6 orders of magnitude
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Ion Source
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Turbo V (Standard ESI / APCI)
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Detector
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AcQuRate Pulse Ion Counting Detector (HED)
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Ion Guide
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QJet-2 Ion Guide
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Key Scan Modes
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MRM, MRM3, EPI, EMS, MS3, Precursor Ion, MRM-IDA-EPI
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Optional Tech
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SelexION Differential Ion Mobility Spectrometry (DMS)
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Data System
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Analyst Software or SCIEX OS (supports 21 CFR Part 11)
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Key Applications
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DMPK/Bioanalysis, Clinical TDM, Food/Env. Residues, Forensics, Metabolomics
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