The used AB SCIEX QTRAP 6500 LC-MS/MS system is a high-performance, hybrid triple quadrupole/linear ion trap mass spectrometer that delivers industry-leading sensitivity, speed, and versatility for complex quantitative and qualitative analyses. Powered by the revolutionary IonDrive technology, this platform maximizes ion generation, transmission, and detection. The redesigned IonDrive Turbo V source enhances gas flow dynamics to produce a higher yield of ions, while the IonDrive QJet ion guide efficiently focuses and transmits ions, minimizing neutral noise. Coupled with the IonDrive High Energy Detector+, the system achieves exceptional signal-to-noise ratios and sub-femtogram limits of detection, making it ideal for trace-level quantification in demanding biological, environmental, and chemical matrices. Its hybrid architecture allows for simultaneous high-sensitivity MRM (Multiple Reaction Monitoring) quantitative analysis and confirmatory qualitative scans (such as Enhanced Product Ion scans) within a single injection, significantly boosting productivity for applications like metabolite identification, impurity profiling, and forensic toxicology.
Performance and throughput are standout features of the QTRAP 6500. It offers a linear dynamic range of up to six orders of magnitude, enabling the simultaneous quantification of analytes across a vast concentration spectrum without sample dilution. With scan speeds of up to 20,000 Da/s (in ion trap mode) and polarity switching as fast as 5 milliseconds, it perfectly matches the elution profiles of modern UHPLC systems, supporting rapid gradients and high-sample-throughput workflows. The standard IonDrive Turbo V source accommodates both Electrospray Ionization (ESI) and Atmospheric Pressure Chemical Ionization (APCI) probes, covering a wide range of compound polarities and molecular weights (5–2,000 m/z). Optional SelexION+ Differential Ion Mobility Spectrometry (DMS) further enhances selectivity by separating isobaric interferences based on ion size and shape, effectively reducing background noise in complex extracts without compromising quantitative sensitivity. Control and data analysis are handled via the intuitive Analyst software or the advanced SCIEX OS platform, both offering compliance-ready features such as audit trails, electronic signatures, and user management to meet FDA 21 CFR Part 11 and GMP/GLP requirements.
This used system is a cost-effective powerhouse across multiple industries. In pharmaceutical R&D, it is a gold standard for DMPK studies, bioanalysis of drug candidates and metabolites in biological fluids, and ultra-trace quantification of impurities or host cell proteins (HCPs). Clinical laboratories utilize it for therapeutic drug monitoring (TDM), neonatal screening (e.g., amino acids, acylcarnitines), and biomarker validation. It excels in food safety and environmental testing for multi-residue pesticide and veterinary drug analysis, mycotoxin detection, and monitoring contaminants like PFAS in water and soil. Academic and biotechnology sectors employ it for metabolomics, proteomics, lipidomics, and complex matrix analysis. When paired with a compatible UHPLC, this refurbished QTRAP 6500 delivers exceptional value, delivering reliable, publication-quality data and empowering labs to achieve high-end results at a fraction of the cost of a new instrument.
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Item
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Specification
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System Type
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Hybrid Triple Quadrupole / Linear Ion Trap (QTRAP 6500)
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Mass Range
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5 – 2,000 m/z (Triple Quad); 50 – 2,000 m/z (Linear Ion Trap)
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Sensitivity (ESI+)
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1 pg Reserpine, S/N ≥ 500,000:1 (MRM mode, typical)
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Scan Speed
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Up to 20,000 Da/s (Ion Trap); 12,000 Da/s (Quadrupole)
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Polarity Switching
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≤ 5 ms (MRM mode)
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Dynamic Range
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Up to 6 orders of magnitude
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Ion Source
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IonDrive Turbo V (Standard ESI / APCI)
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Detector
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IonDrive High Energy Detector (HED)
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Ion Guide
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IonDrive QJet (Dual-stage)
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Collision Cell
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Curved LINAC (High capacity, reduced cross-talk)
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Optional Tech
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SelexION+ Differential Ion Mobility Spectrometry (DMS)
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Data System
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Analyst Software or SCIEX OS (supports 21 CFR Part 11)
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Key Applications
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DMPK, Bioanalysis, Clinical TDM, Food/Environmental Residues, Omics
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