The used AB SCIEX QTRAP 5500+ LC-MS/MS system is a highly versatile and cost-effective hybrid triple quadrupole/linear ion trap mass spectrometer, designed to deliver exceptional quantitative sensitivity and qualitative confirmation in a single injection. As an upgraded iteration of the renowned 5500 series, this "QTRAP Ready" platform combines the robust MRM (Multiple Reaction Monitoring) quantification capabilities of a triple quad with the structural elucidation power of a linear ion trap. At its core, the system utilizes a high-sensitivity Turbo V ion source (compatible with ESI and APCI) and a high-energy dynode detector, enabling remarkable sensitivity with a linear dynamic range of up to six orders of magnitude. It supports rapid polarity switching (as fast as 5 ms) and high scan speeds (up to 12,000 Da/s in Q1 and 20,000 Da/s in the ion trap), making it perfectly suited to match fast UHPLC gradients and high-throughput workflows. The ability to run advanced scan modes—such as MRM3 (MS/MS/MS) for enhanced selectivity in complex matrices and EPI (Enhanced Product Ion) scans for spectral library matching—allows researchers to quantify trace-level analytes while simultaneously confirming their identity, effectively eliminating false positives.
This refurbished system serves as a workhorse across a vast array of demanding applications. In pharmaceutical R&D and DMPK studies, it is extensively used for the quantitative bioanalysis of drug candidates and metabolites in biological fluids (plasma, urine, tissues) and for biomarker validation. Clinical and forensic laboratories rely on the QTRAP 5500+ for therapeutic drug monitoring (TDM), neonatal screening panels (e.g., amino acids, acylcarnitines), and comprehensive toxicology screens. Furthermore, it is a gold standard in food safety and environmental testing for the multi-residue analysis of pesticides, veterinary drugs, mycotoxins, and contaminants like PFAS in water and soil, where regulatory limits demand extreme sensitivity and specificity. The optional compatibility with SelexION+ Differential Ion Mobility Spectrometry (DMS) adds an extra dimension of separation, resolving isobaric interferences and reducing background noise in complex extracts without sacrificing quantitative performance. Controlled via the intuitive Analyst software or the advanced SCIEX OS platform, the system supports scheduled MRM algorithms to maximize the number of compounds analyzed in a single run and includes compliance-ready features (audit trails, electronic signatures) to meet FDA 21 CFR Part 11 and GMP/GLP requirements.
Opting for a used AB SCIEX QTRAP 5500+ offers laboratories access to premium, field-proven technology at a significantly reduced capital expenditure. These systems are known for their outstanding robustness, long-term stability, and high uptime, provided they are properly refurbished and validated (e.g., passing a 1 pg reserpine sensitivity test). For facilities requiring flexible, high-sensitivity LC-MS/MS capabilities—ranging from routine quantitative assays to complex qualitative identification—without the budget for a brand-new instrument, a verified used QTRAP 5500+ represents an ideal balance of performance, reliability, and value. It empowers labs to generate publication-quality data and meet stringent regulatory standards efficiently, making it a smart investment for pharmaceutical, clinical, forensic, food, and environmental testing laboratories alike.
|
Item
|
Specification
|
|
System Type
|
Hybrid Triple Quadrupole / Linear Ion Trap (QTRAP 5500+)
|
|
Mass Range
|
5 – 1,250 m/z (standard); optional 5 – 2,000 m/z
|
|
Sensitivity (MRM)
|
1 pg Reserpine, S/N ≥ 750,000:1 (typical)
|
|
Scan Speed
|
Up to 12,000 Da/s (Q1); Up to 20,000 Da/s (Ion Trap)
|
|
Polarity Switching
|
≤ 5 ms
|
|
Dynamic Range
|
Up to 6 orders of magnitude
|
|
Ion Source
|
Turbo V (Standard ESI / APCI)
|
|
Detector
|
High Energy Dynode (HED) Detector
|
|
Key Scan Modes
|
MRM, MRM3, EPI, EMS, MS3, Precursor Ion, Neutral Loss
|
|
Optional Tech
|
SelexION+ Differential Ion Mobility (DMS)
|
|
Data System
|
Analyst Software or SCIEX OS (supports 21 CFR Part 11)
|
|
Key Applications
|
DMPK/Bioanalysis, Clinical TDM, Food/Env. Residues, Forensics
|
bio-equip.cn
中文
