Diacylglycerol kinase alpha (DGKA) is an enzyme encoded by the DGKA gene in humans and belongs to the eukaryotic diacylglycerol kinase family. It is involved in intracellular signaling pathways, acting as a modulator that competes with protein kinase C for the second messenger diacylglycerol. DGKA also plays a crucial role in the resynthesis of phosphatidylinositols and the phosphorylation of diacylglycerol to phosphatidic acid. Additionally, DGKA has been identified as a potential candidate in radiation-induced fibrosis, where its expression can be induced by the transcription factor EGR1, leading to enhanced production of pro-fibrotic ECM proteins such as collagen and fibronectin.
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