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Closed Material Transfer Valve（α,β Valve）
- Product Detail
- Company Profile
- Closed Material Transfer Valve（α,β Valve）
Description
An Alpha Beta valve (Split butterfly valve) system is consist of an active
and a passive valve which adopts well-designed split butterfly valve
technology. Realize contained transfer of material, and the transfer
process guarantees the sterile situation won't be destroyed or avoid
being spread of the toxic materials in the container. Including feeding,
charging, dispensing, sampling, etc. αβ valve has two
types: Conventional and clean/sterilization in place.
Purpose of use
1. Ensure production process meet GMP, product quality requirement and industry supervision
2. Operator protection- Avoiding the leakage of toxic materials during transfer process which is harmful for operator
3. Protection of sterile product-Guarantee the transfer process of sterile product avoiding being effected by outside microbe
4. Eliminate loss of product yield during transfer.
5. Reduce the potential risk of product cross-contamination and manual intervention
6. Reduce requirement for high demand clean area and cumbersome personal protection
7. Effective dust control during transfer process, ensure dust-free environment
Application
Pharmaceutical/ Biotechnology /Chemical /Food/ Beverage /Nuclear /CDC
Model and interface size reference table
| Type | CSBV50 | CSBV65 | CSBV80 | CSBV100 | CSBV150 | CSBV200 | CSBV250 |
| Imperial system | 2" | 3" | 3 1/2" | 4" | 6" | 8" | 10" |
| External size of interface | 64mm | 91mm | 106mm | 119mm | 167mm | 218mm | 268.5mm |
Application case
-Sterile API transfer and subpackage
-Isolator charging and discharging
-Contained dispensing, charging, discharging, sampling and milling
-Containment transfer of sterile rubber plug
-Transfer toxic product
Technical Parameter
-Valve disc surface sealing by metal to metal
-Body material: 316L stainless steel
-Sealing material: FKM
-OEL：≤10μg/m3，OEB：≥4
-Endure Pressure:≥0.25MPa
-Standard clamp interface, accept customized corresponding interface
-Outside of container operate valve switch and product transfer
-Comply with the cGMP, FDA, EU production requirements
Feature
-Valve disc surface sealing by metal to metal
-Food grade FKM seat
-Multi-interlock function, avoiding error operation
-With clean/sterilization in place function
-Efficient cleaning and maintenance
-Easy and fast to install
-Suit for non-containment material transfer system which need improve
Type
Standard size：50mm，65mm，80mm，100mm，150mm，200mm，250mm
Interface：PN6，PN10，ANSI#150，Tri-Clamp
Customized size：
Accept customized non-standard size
αβ valve -Conventional don't set isolation valve inlet and outlet, can't clean/sterilize the valve disk exposed face in place. People can wash and
sterilize the exposed face by manual work to reach the normative requirement of material transfer.
Process
First step.Prepare docking — —Active valve and passive valve prepare docking. Each valve has one half disk, and each valve is both sealed
independently which can’t open until two halves valve disks combined.
Second step.Disks combined — — Two halves valve disks combined. The previously exposed faces are now sealed together to form a single
butterfly valve disk.
Third step.Material transfer——Active valve is the driving of butterfly valve disk. Once operate disk will open to allow the material being transferred
through the valve. Once open, active valve and passive valve can’t split because of Interlock design.
Forth step.Valve split——Operate disk to close after finishing transferring material. Active valve and passive valve form two independent sealed unit.
Then unlock of two valves, ensure the split.
Clean/sterilization in place type of αβ valve set isolation inlet and outlet, can clean/sterilize the valve disk
exposed face in place, then carry on active and passive valve combined and split, guarantee safety of material or environment.
CIP(Clean in place)
After material being transferred, active and passive valve operate
to be apart, start interval self-lock device, adopts clean air or
purified water to clean exposed face
SIP(Sterilization in place)
Active and passive valve prepare docking , before combined of two
disks, start interval self-lock device. Purge with VHP to
decontaminate the exposed face.
Welcome to inquire, E-mail：pangjun@costones.com
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Suzhou COSTONES Instruments Co., Ltd. (COSTONES) is an instrument company focusing
on separation and purification. It is an equipment supplier and service provider
for biopharmaceutical, cell therapy and gene testing. It is committed to providing
users with industry-leading technical support and services.
The company has a perfect service system and executive power. It interprets the
user experience from the four aspects of technical communication, scheme design,
technical support and after-sales service, and tries to achieve seamless connection
in every link until it is recognized by customers.
For a long time, we have maintained good cooperative relations with domestic and
foreign suppliers. The main products include protein purification system,
compressible chromatographic column, ultrafiltration system, chromatographic
ultrafiltration accessories, etc., and provide maintenance services and customized
product services;
At present, Suzhou quarrying has provided high-quality services for
biopharmaceutical, cell therapy, research institutes and scientific research users.
It has carried out in-depth cooperation with customers and become a reliable partner
for customers to achieve win-win results.
We take quality first as the standard, quickly respond to customer needs, help
customers solve problems, improve efficiency, and take improving core
competitiveness for customers as our service tenet. We are willing to realize our
own value while creating value for customers and society through our unremitting
efforts.
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