Protein tyrosine phosphatase, non-receptor type 11 encoded by PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for PTPN11.
The Abbkine SH-PTP2 (phospho Tyr542) Rabbit Polyclonal Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and detects endogenous levels of SH-PTP2 protein only when phosphorylated at Y542. The antibody has been validaed in WB , IHC-P, ELISA and reacts with Human, Mouse, Rat samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Rabbit Anti-SH-PTP2 (phospho Tyr542) Polyclonal Antibody at https://www.abbkine.com/product/sh-ptp2-phospho-tyr542-polyclonal-antibody-abp50456.
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