Protein kinase AMP-activated catalytic subunit alpha 1 encoded by PRKAA1 belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
The Abbkine AMPKα1/2 (phospho Thr183/172) Rabbit Polyclonal Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and detects endogenous levels of AMPKα1/2 protein only when phosphorylated at T183/172. The antibody has been validaed in WB , IF, IHC-P, ELISA and reacts with Human, Mouse, Rat, Monkey samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Rabbit Anti-AMPKα1/2 (phospho Thr183/172) Polyclonal Antibody at https://www.abbkine.com/product/ampkα1-2-phospho-thr183-172-polyclonal-antibody-abp50452.
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