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Phrixotoxin-3
Place of Origin:
France
Brand:
Smartox
Model:
0.1 mg
Supplier:
Smartox Biotech
Price:
200 €
Hits:
1377 
Updated:
6/18/2014
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  • Product Detail
  • Company Profile
    Phrixotoxin-3 (Paurtx-3), Selective blocker of Nav1.2 Phrixotoxin-3 (PaurTx3 or Beta-theraphotoxin-Ps1a) is a valuable pharmacological tool to study voltage-gated sodium channels. Phrixotoxin-3, originally issued from the venom of the tarantula phrixotrichus auratus, has been shown to inhibit Nav1.1, Nav1.2, Nav1.3, Nav1.4 and Nav1.5 with respective IC50 values of 610 nM, 0.6 nM, 42 nM, 288 nM and 72 nM. It is thus considered as one of the most potent and almost selective modulator of Nav1.2. Phrixotoxin-3 technical information AA sequence: Asp-Cys2-Leu-Gly-Phe-Leu-Trp-Lys-Cys9-Asn-Pro-Ser-Asn-Asp-Lys-Cys16-Cys17-Arg-Pro-Asn-Leu-Val-Cys23-Ser-Arg-Lys-Asp-Lys-Trp-Cys30-Lys-Tyr-Gln-Ile-OH Disulfide bridges: Cys2-Cys17, Cys9-Cys23, and Cys16-Cys30 Length (aa): 34 Formula: C171H245N53O47S6 Molecular Weight: 4059.9 Da Appearance: White lyophilized solid Solubility: water or saline buffer CAS number: Not available Source: Synthetic Purity rate: > 97 % http://www.smartox-biotech.com/en/sodium-channel/262-phrixotoxin3
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
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