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ProTx-I
Place of Origin:
France
Brand:
Smartox
Model:
0.1 mg
Supplier:
Smartox Biotech
Price:
135 €
Hits:
1393 
Updated:
6/18/2014
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  • Product Detail
  • Company Profile
    Protoxin I / ProTx-I, Blocker of voltage-gated sodium channels Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2. ProTx-I technical information AA sequence: Glu-Cys2-Arg-Tyr-Trp-Leu-Gly-Gly-Cys9-Ser-Ala-Gly-Gln-Thr-Cys15-Cys16-Lys-His-Leu-Val-Cys21-Ser-Arg-Arg-His-Gly-Trp-Cys28-Val-Trp-Asp-Gly-Thr-Phe-Ser Disulfide bridges: Cys2-Cys16, Cys9-Cys21, Cys15-Cys28 Length (aa): 35 Formula: C171H245N53O47S6 Molecular Weight: 3987.50 Da Appearance: White lyophilized solid Solubility: water or saline buffer CAS number: Not available Source: Synthetic Purity rate: > 95 % http://www.smartox-biotech.com/en/sodium-channel/257-protx-i
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
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