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Peptide Synthesizer（R&D）
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- Peptide Synthesizer（R&D）
Product Introduction
This compact fully‑automatic peptide synthesizer is well‑suited for synthesizing peptides of moderate difficulty and longer sequences. Widely adopted in universities, research institutes and pharmaceutical factories, it supports general peptide research, peptide drug and vaccine R&D, and drug regulatory filing applications.
High‑level automation enables unattended full‑automatic synthesis for up to 48 hours, greatly freeing researchers’ hands. Operators only need to prepare reagents and edit programs in advance; the instrument will complete all remaining procedures automatically.
Product Functions
The peptide synthesizer is mainly designed for Solid‑Phase Peptide Synthesis (SPPS). It automatically performs amino‑acid coupling and batch preparation of peptide fragments, and is extensively applied in drug research & development, antigen peptides, diagnostic reagents, cosmetic raw materials and other fields.
- Synthesis Mode: Fmoc
- Activation Reagents: HOBT/DIC/DCC/HBTU/HATU/Oxyma, etc.
- Amino‑acid Addition: Automatic
- Overall Dimension: 80 cm(W) × 54 cm(D) × 73 cm(H)
1. Amino‑acid Feeding and Reagent Delivery
- Automatically delivers protected amino acids, activators, deprotection agents and washing solvents;
- Precisely controls reagent volumes and executes reagent feeding and liquid discharge according to programmed protocols;
- Supports multiple amino‑acid positions for synthesis of peptides with different sequences.
2. Deprotection (Fmoc/Boc Removal)
- Fmoc strategy: Amino‑protecting group removal using piperidine;
- Boc strategy: Acid‑mediated deprotection;
- Reaction time and temperature are controlled to fully expose resin‑bound amino groups for subsequent coupling reactions.
3. Amino‑acid Activation and Coupling Reaction
- On‑line activation: Activators (HBTU, HATU, DIC, etc.) activate carboxyl groups;
- Activated amino acids react with free amino groups on resin to form peptide bonds;
- Coupling time, temperature and equivalents can be configured to improve coupling efficiency;
- Double‑coupling is supported for difficult‑to‑coupling sites to reduce deletion‑sequence impurities.
4. Resin Washing
- Automatic repeated solvent washing after each deprotection and coupling cycle;
- Removes residual reagents, unreacted amino acids and by‑products;
- Suppresses side reactions and minimizes peptide‑related impurities.
5. Reaction Temperature Control
- Room‑temperature / heated synthesis; low‑temperature mode available for selected models;
- Heating improves coupling efficiency for sterically‑hindered amino acids and shortens synthesis cycles.
6. Nitrogen Agitation / Bubbling Mixing
- Resin is agitated by nitrogen bubbling instead of mechanical stirring;
- Resin particles are fully suspended to ensure uniform solid‑liquid contact and complete reactions.
7. Nitrogen Blowing, Liquid Discharge and Waste‑Liquid Collection
- Automatic waste‑liquid drainage upon reaction completion;
- Resin drying via nitrogen purge;
- Segregated waste‑liquid collection tanks for acids, bases and organic solvents.
8. Program Editing and Execution
- Customize peptide sequences for automatic generation of synthesis workflows;
- Modify step‑wise parameters including reaction time, reagent dosage and cycle count;
- Real‑time operation status monitoring, fault alarm and synthesis log recording.
9. Crude‑peptide Preparation before Cleavage (On‑instrument)
Fully‑protected peptide bound to resin is obtained upon synthesis completion.
10. Throughput Modes
- Single‑column synthesis: For long‑chain peptides and hard‑to‑synthesize peptides;
- Multi‑channel parallel synthesis: Simultaneous synthesis of multiple distinct sequences for screening purposes.
Product Specifications
| Synthetic scale | Reactor | Heating or not |
| 0.1-0.5mmol | 40ml | Optional |
| 0.1-1.25mmol | 140ml | Optional |
Product features:
• no dead angle mixing design. The mixing system uses a 180 ° up and down motion to ensure uniform mixing and completely eliminate the dead angle. The average coupling rate is more than 99%. It is especially suitable for the synthesis of long peptides and highly difficult peptides, and meets the needs of scientific research. An excellent reagent delivery system is designed to clean the reagent up to any point on the tube, completely eliminating the cross contamination of the reagent
• peptide synthesis can be controlled automatically in the whole process. The addition of amino acids and reagents, stirring speed and reaction time can be set by modular program
• record every step of the reaction in the whole process and automatically save it in the database. Password protection prevents any unauthorized operation
• each synthesis step is intuitively displayed on the screen in the form of a chart, which is easy to understand the progress of synthesis at any time
• synthetic data is recorded and automatically saved throughout the process, which is conducive to the patent application of new drugs
Application scenarios: the peptide synthesis instrument is based on solid-phase peptide synthesis SPPs to realize automatic peptide chain assembly, covering the whole chain of basic scientific research, drug research and development, diagnostic reagents, and process amplification. It is divided into three scenarios according to scale: laboratory research and development, pilot test, and production.
1、 Universities and scientific research institutes (small test, Mg ‑ g level)
1. basic biological research
-Synthesis of antigen peptide and epitope peptide for antibody preparation;
-Synthesis of signal peptide, cell penetrating peptide and antimicrobial peptide, and carry out cell and in vitro function experiments;
-Protein fragments were synthesized to study protein interactions and enzyme substrates.
2. chemical biology research
-Synthesis of modified peptide: phosphorylated peptide, biotin labeled peptide, fluorescent labeled peptide, cyclic peptide;
-Development of peptide conformation and peptide chemistry methodology;
-Multiple peptides were synthesized in parallel for activity screening.
Equipment: small multi-channel peptide synthesis instrument, which can synthesize multiple different sequences at one time, and the flux is preferred.
2、 Bio pharmaceutical cro
1. early screening of drugs
-A large number of candidate peptide molecules were synthesized for rapid screening of activity;
-Preparation of peptide drug candidates, in vitro/in vivo pharmacological experiments of donors;
2. customized peptide service
Provide customized peptide synthesis business, deliver crude peptide or deprotection resin products to universities and pharmaceutical enterprises.
Equipment: small and medium-sized synthesis instrument, taking into account the parallel of single long peptide and multiple sequences.
3、 Pharmaceutical enterprises (innovative drugs, peptide APIs)
1) Drug development stage
-Synthesis of GLP ‑ 1, somatostatin, thymosin, oxytocin and other peptide candidate drugs;
-Process development: optimize coupling time, temperature and reagent equivalent to establish a stable solid-state synthesis process;
-Prepare preclinical samples for pharmacodynamic and toxicological tests.
2) Pilot scale up (g ‑ kg level)
-Process transfer to enlarge the scale of solid-phase synthesis;
-GMP traceability log to meet the requirements of application materials;
-Production of clinical batch samples.
Equipment: pilot scale, GMP production type peptide synthesis instrument, large feeding of single reactor, complete audit tracking.
4、 IVD industry for in vitro diagnosis
-Synthetic peptide antigen for ELISA, colloidal gold and chemiluminescence diagnostic reagent;
-Synthesis of specific epitope peptides and development of diagnostic kits for autoimmune diseases and infections;
>Features: the sequence is relatively fixed, the batch stability is required, and the repeatability is preferred.
5、 Other industrial application scenarios
1. cosmetics raw materials: research and development of signal peptide and beauty active peptide raw materials;
2. agricultural peptides: research and development of pesticide candidate molecules of plant derived active peptides and antimicrobial peptides;
3. peptide library construction: combined peptide library, high-throughput screening of active molecules.
Welcome to inquire, pangjun@costones.com
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Suzhou COSTONES Instruments Co., Ltd. (COSTONES) is an instrument company focusing
on separation and purification. It is an equipment supplier and service provider
for biopharmaceutical, cell therapy and gene testing. It is committed to providing
users with industry-leading technical support and services.
The company has a perfect service system and executive power. It interprets the
user experience from the four aspects of technical communication, scheme design,
technical support and after-sales service, and tries to achieve seamless connection
in every link until it is recognized by customers.
For a long time, we have maintained good cooperative relations with domestic and
foreign suppliers. The main products include protein purification system,
compressible chromatographic column, ultrafiltration system, chromatographic
ultrafiltration accessories, etc., and provide maintenance services and customized
product services;
At present, Suzhou quarrying has provided high-quality services for
biopharmaceutical, cell therapy, research institutes and scientific research users.
It has carried out in-depth cooperation with customers and become a reliable partner
for customers to achieve win-win results.
We take quality first as the standard, quickly respond to customer needs, help
customers solve problems, improve efficiency, and take improving core
competitiveness for customers as our service tenet. We are willing to realize our
own value while creating value for customers and society through our unremitting
efforts.
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