IL-31 Protein, Mouse,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Mouse
Synonyms	Interleukin-31; IL-31;
Accession	Q6EAL8
Amino Acid Sequence	Thr24-Cys163, with C terminal His Tag.
Expression System	HEK293
Molecular Weight	20-40 kDa (Reducing)
Purity	>95% by SDS-PAGE; >90% by HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Nat Immunol. 2004 Jul;5(7):752-60. Epub 2004 Jun 6.

Background

Interleukin-31 (IL-31) is a cytokine that belongs to the IL-6 cytokine family and is primarily produced by activated T helper type 2 (Th2) cells. IL-31 signals through a heterodimeric receptor complex composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor (OSMR), leading to the activation of downstream signaling pathways such as STAT1 and STAT3. IL-31 is involved in various inflammatory and immune responses, and has been implicated in the pathogenesis of allergic diseases, skin disorders, and chronic inflammatory conditions. In mouse models, IL-31 has been shown to play a role in pruritus (itching) and dermatitis, highlighting its importance in mediating inflammatory responses in the skin.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.