CXADR/CAR His Tag Protein, Mouse,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Mouse
Synonyms	Coxsackievirus and adenovirus receptor homolog, CAR, Cxadr, CVB3 BP
Accession	NP_001020363.1
Amino Acid Sequence	Ala2-Gly237 with His Tag at C-Terminus
Expression System	HEK293
Molecular Weight	32-34kDa (Reducing)
Purity	＞95% by SDS-PAGE & SEC-HPLC
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Philipson, L. et al., 2004, Curr. Top. Microbiol. Immunol. 273:87-111. 2.Raschperger, E. et al., 2006, Exp. Cell Res. 312: 1566-1580.

Background

CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein that belongs to the CTX family within the immunoglobulin (Ig) superfamily. It is crucial for normal cardiac development in mice. CXADR is proposed to function as a homophilic cell adhesion molecule and is a component of the epithelial apical junction complex, which is essential for maintaining tight junction integrity. It is also likely involved in the transepithelial migration of polymorphonuclear leukocytes (PMNs).
The mature mouse CXADR structure consists of a 218 amino acid (aa) extracellular domain (ECD), which includes a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment, and a 17 aa intracellular domain. Notably, D1 is believed to be responsible for homodimer formation within tight junctions. The ECD of mouse CXADR shares 97% sequence identity with the corresponding regions of human CXADR and 9% sequence identity with those of rat CXADR.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.