Interleukin-17F (IL-17F) is a member of the interleukin-17 cytokine family that plays a key role in regulating inflammatory responses and immune reactions. IL-17F is primarily produced by activated T cells, particularly Th17 cells, and acts on various cell types, including epithelial cells, fibroblasts, and immune cells. IL-17F is involved in the pathogenesis of inflammatory and autoimmune diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. It promotes the production of pro-inflammatory cytokines and chemokines, leading to recruitment of immune cells to sites of inflammation and tissue damage.
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