E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells. It is sometimes implicated in cancer cell metastasis. E-selectin features a complex mosaic structure, which includes a large extracellular region composed of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain. This is followed by a transmembrane region and a relatively short cytoplasmic tail of 32 amino acids (aa).
As a member of the selectin family, E-selectin recognizes and binds to sialylated carbohydrates, including those belonging to the Lewis X and Lewis A families, which are found on the surface of monocytes, granulocytes, and T-lymphocytes. It supports the rolling and stable arrest of leukocytes on activated vascular endothelium. Additionally, E-selectin has been shown to transduce an activating stimulus via the mitogen-activated protein kinase (MAPK) cascade into the endothelial cell during leukocyte adhesion.
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