E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes implicated in cancer cell metastasis. It has a complex mosaic structure that includes a large extracellular region with a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain. This is followed by a transmembrane region and a relatively short (32 amino acid) cytoplasmic tail. As part of the LEC-CAM or selectin family, E-selectin recognizes and binds to sialylated carbohydrates, including those from the Lewis X and Lewis A families, which are found on monocytes, granulocytes, and T-lymphocytes. It facilitates the rolling and stable arrest of leukocytes on activated vascular endothelium. Additionally, E-selectin is suggested to transduce activating stimuli via the MAPK signaling cascade during leukocyte adhesion.
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