Fas, also known as APO-1 or CD95, belongs to the death receptor subfamily of the TNF receptor superfamily and is a prototypical death receptor characterized by the presence of an 80-amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant.
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