Semaphorin 4D is a 150 kDa type I transmembrane glycoprotein that belongs to the Class 4 family of transmembrane immune and nervous system semaphorins. Semaphorin 4D, also known as CD100, is an important member of the semaphorin family and was first characterized as a lymphocyte-specific marker. Semaphorins play crucial roles in regulating multiple biological processes, such as neural remodeling, tissue regeneration, cancer progression, and, especially, in immunological regulation. Sema4D, produced by T cells, activated B cells and dendritic cells acts through a low affinity receptor termed CD72 in the immune system.In cancer, Sema4D can also be produced by tumor-associated macrophages, and bind to endothelial cell Plexin B1, thus promoting tumor angiogenesis.
中文
