Human Epidermal growth factor Receptor 2
(HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2,
and is a protein giving higher aggressiveness in breast cancers. It is a member
of the ErbB protein family, more commonly known as the epidermal growth factor
receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase
and is normally involved in the signal transduction pathways leading to cell
growth and differentiation. Human ErbB2 consists of 1255 amino acids (aa)
including a 22 aa signal sequence, a 630 aa extracellular domain (ECD), a 23 aa
transmembrane region, and a 580 aa cytoplasmic domain. HER2 appears to play
roles in development, cancer, communication at the neuromuscular junction and
regulation of cell growth and differentiation. Phosphoinositide 3-kinase has
been shown to play a role in ErbB2 signal transduction. The cytoplasmic domain
of ErbB2 has been shown to associate with beta-catenin and plakoglobin.
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