Cluster
of differentiation 38 (CD38) is a multifunctional extracellular enzyme on the
cell surface with NADase and cyclase activities. As a NADase, CD38 produces
adenosine through the adenosine energy pathway to cause immunosuppression. As a
cell surface receptor, CD38 is necessary for immune cell activation and
proliferation. Previous studies suggested that CD38 plays an important role in
the regulation of macrophage function.
Therefore, as a new marker of macrophages, the effect of CD38 on
macrophage proliferation, polarization and function, its possible mechanism;
CD38 is not only expressed in human immune cells, such as lymphocytes and
plasma cells, but also is abnormally expressed in a variety of tumor cells,
which is closely related to the occurrence and development of tumors. The role of CD38 in immune cells ranges from
modulating cell differentiation to effector functions during inflammation,
where CD38 may regulate cell recruitment, cytokine release, and NAD
availability. In line with a role in inflammation, CD38 appears to also play a
critical role in inflammatory processes during autoimmunity, although whether
CD38 has pathogenic or regulatory effects varies depending on the disease,
immune cell, or animal model analyzed.
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