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Human PIN1 Protein, His tag
Human PIN1 Protein, His tag
Place of Origin:
Singapore
Brand:
Starter
Model:
S0A0126-25μg
Price:
185
Hits:
Updated:
8/25/2025
  • Product Detail
  • Company Profile

    Product Specification


    SpeciesHuman
    SynonymsPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1, EC:5.2.1.8, Peptidyl-prolyl cis-trans isomerase Pin1 (PPIase Pin1), Rotamase Pin1
    AccessionQ13526
    Amino Acid Sequence

    Protein sequence (Q13526, Met1-Glu163, with C-His tag) MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE

    Expression SystemE.coli
    Molecular WeightPredicted MW: 19.9 kDa Observed MW: 19.9 kDa
    Purity>95% by SDS-PAGE
    Endotoxin<0.1EU/μg
    ConjugationUnconjugated
    Tagwith C-His tag
    Physical AppearanceLyophilized Powder
    Storage BufferLyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
    ReconstitutionReconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
    Stability & Storage

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

    Background

    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene. Pin 1, or peptidyl-prolyl cis/trans isomerase (PPIase), isomerizes only phospho-Serine/Threonine-Proline motifs. The enzyme binds to a subset of proteins and thus plays a role as a post phosphorylation control in regulating protein function. Studies have shown that the deregulation of Pin1 may play a pivotal role in various diseases. Notably, the up-regulation of Pin1 is implicated in certain cancers, and the down-regulation of Pin1 is implicated in Alzheimer's disease. Inhibitors of Pin1 may have therapeutic implications for cancer and immune disorders.

    bio-equip.cn
    AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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