Phospho-PKR (Thr446) Recombinant Rabbit mAb (S-771-17),Starter_specification/price/image

Product Detail
Company Profile

Product Specification

Host	Rabbit
Antigen	Phospho-PKR (Thr446)
Synonyms	Interferon-induced, double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2 (eIF-2A protein kinase 2); Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; Protein kinase RNA-activated (PKR; Protein kinase R); Tyrosine-protein kinase EIF2AK2; p68 kinase; PKR; PRKR; EIF2AK2
Immunogen	Synthetic Peptide
Location	Cytoplasm, Nucleus
Accession	P19525
Clone Number	S-771-17
Antibody Type	Recombinant mAb
Isotype	IgG
Application	WB
Reactivity	Hu
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 掳C as supplied

Dilution

application	dilution	species
Dot Blot	1:1000
WB	1:500	Hu

Background

Protein Kinase R (PKR), also known as double-stranded RNA-dependent protein kinase, is a key enzyme involved in the innate immune response to viral infections. It is an interferon-induced, serine/threonine protein kinase that becomes activated upon binding to double-stranded RNA (dsRNA), which is often produced during viral replication. Once activated, PKR phosphorylates the eukaryotic initiation factor 2伪 (eIF-2伪), inhibiting protein synthesis and thus limiting viral replication. Additionally, PKR plays roles in regulating apoptosis, cell growth, and differentiation, and has been implicated in cancer and metabolic diseases. Its versatile functions make it a significant target for therapeutic research.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.