Solid-phase peptide synthesizer automates the sequential addition of amino acids to a growing peptide chain anchored to a solid resin support.
This method, known as solid-phase peptide synthesis(SPPS), significantly enhances the efficiency and accuracy of peptide production.
Basic Technical Specifications:
1. Volume: 100ml, 200ml, 500ml, 1L, 2L, 3L, 5L, 10L, 20L, 30L, 50L, 100L, form laboratory scale to pilot plant and industrial scale.
2. Vessel: Single wall, double wall or triple wall available
3. Working pressure: Full vacuum to 0.05/0.1Mpa
4. Working temperature: -80°C ~ +220°C
5. Wetted parts: Borosilicate glass 3.3, PTFE
6. Filter device: PTFE, glass or stainless-steel, pore size 0.1um to 200um
A solid-phase peptide synthesizer includes several key components that work together seamlessly to automate peptide synthesis.
Key Components
1. Reaction Vessel:
The reaction vessel serves as the central chamber where peptide synthesis occurs.
Typically made from inert materials like borosilicate glass or stainless steel, the reaction vessel ensures chemical resistance and durability.
Within this vessel, the resin, which acts as the solid support, is housed. It design allows for easy mixing and washing, crucial for successful synthesis.
2. Resin:
The resin is a crucial component as it anchors the first amino acid and supports the growing peptide chain throughout the synthesis process.
The resin’s properties significantly influence the efficiency and yield of the peptide synthesis.
3. Reagent Delivery System:
A precise reagent delivery system is essential for accurately dispensing amino acids, coupling reagents, deprotection agents, and solvents into the reaction vessel.
Automated pumps and valves control the flow of these reagents, ensuring that each step of the synthesis process is executed with high precision.
4. Mixing and Agitation Mechanism:
Effective mixing is vital to ensure uniform distribution of reagents and optimal contact with the resin.
Solid-phase peptide synthesizers often incorporate magnetic stirrers or mechanical agitators to achieve this.
Proper mixing and agitation prevent incomplete reactions and enhance the overall efficiency of the synthesis process.
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For more information, please visit us:
Solid Phase Peptide Synthesizer
https://njhjchem.com/product/glass-nutsche-filters/automated-solid-phase-peptide-synthesizer/
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