The perfect activator for peptide synthesis at elevated temperature.
Overview
OxymaPure® used with DIC produces peptides with increased yield and decreased epimerization when used as an alternative to HOBt1 . This safe, non-explosive auxiliary nucleophile works with carbodiimide coupling strategies to provide the best results for a peptide synthesis. Additionally, the use of DIC/Oxyma avoids side reactions associated with high levels of base (≥ 1 equiv. DIEA) using onium salt methods such as HBTU/DIEA.
1R. Subirós-Funosas, et al. (2009) Chem. Eur. J., 15, 9394.
Features
Extremely fast acylation rates
Non-explosive (compared to HOBt)
Low cost
Highly soluble in peptide synthesis solvents
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