Fibrinogen gamma chain is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots.In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
Human Fibrinogen Gamma Chain (FGG) ELISA Kit employs a two-site sandwich ELISA to quantitate FGG in samples. An antibody specific for FGG has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyFGG present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for FGG is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of FGG bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Fibrinogen Gamma Chain (FGG) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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