NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA (RELA proto-oncogene, NF-kB subunit), or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of RELA, RELA. Four transcript variants encoding different isoforms have been found for RELA.
The Abbkine Acetyl NF kB P65 (K314/K315) Mouse Mouse Monoclonal Antibody (2A11) was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen and detects endogenous Acetyl NF kB P65 (K314/K315) protein. The antibody has been validaed in IHC-P and reacts with Human, Mouse, Rat samples.
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