CBX5 (chromobox 5) encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. CBX5 has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
The Abbkine HP-1α Mouse Mouse Monoclonal Antibody (5E3) was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen and detects endogenous HP-1α protein. The antibody has been validaed in WB, IF, IHC-P and reacts with Human, Mouse, Rat samples.
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