The protein encoded by HSPB8 (heat shock protein family B (small) member 8) belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of HSPB8 in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, HSPB8 appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in HSPB8 have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
The Abbkine HSPB8/HSP22 Mouse Monoclonal Antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody has been validaed in WB and reacts with Human, Mouse, Rat samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Mouse Anti-HSPB8/HSP22 Monoclonal Antibody at https://www.abbkine.com/product/hspb8-hsp22-monoclonal-antibody-abm40233.
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