RAF1 is the cellular homolog of viral raf gene (v-raf). Raf-1 proto-oncogene, serine/threonine kinase is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in RAF1 are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
The Abbkine Raf-1 (phospho Ser338) Rabbit Polyclonal Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and detects endogenous levels of Raf-1 protein only when phosphorylated at S338. The antibody has been validaed in WB , ELISA and reacts with Human, Mouse, Rat samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Rabbit Anti-Raf-1 (phospho Ser338) Polyclonal Antibody at https://www.abbkine.com/product/raf-1-phospho-ser338-polyclonal-antibody-abp50444.
bio-equip.cn
中文
