The product of ERCC1 functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. ERCC excision repair 1, endonuclease non-catalytic subunit forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in ERCC1 result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of ERCC1 may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for ERCC1. The last exon of ERCC1 overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
The Abbkine ERCC1 Mouse Monoclonal Antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen and detects endogenous ERCC1 proteins. The antibody has been validaed in WB and reacts with Human samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Mouse Anti-ERCC1 Monoclonal Antibody at https://www.abbkine.com/product/ercc1-monoclonal-antibody-abm40078.
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