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Hot-melt extruder/Dissolution Process
Hot-melt extruder/Dissolution Process
Place of Origin:
ATS Engineering inc
ZE-16 hot-melt extruder
Enquiry: tongge@atshph.com
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             Hot-Melt  Extrusion  technique or named Melt Extrusion technique,It's a new preparation technology that the Europe, North America and Japan vigorously developed in recent years. The main function is to improve the solubility of the drug, the preparation of sustained release formulations……

    ​        Hot-Melt  Extruder Basic parameters


    Capacity :3kg/h,

    Screw diameter (mm) 15.6

    Screw groove depth (mm) 3.3

    Maximum drive power(Kw) 1.5

    Maximum speed(rpm) 600

    Maximum output torque(N/m) 33

    Molding caliber(mm) 2

    Minimum sample weight(g) :30

    Residues(ml) :20


    Hot-melt extruder Technical advantages:

    Continuous production

    Excellent reproducibility

    No dust pollution

    Online control

    ​Hot-melt extruder Applications:

    1. Adalat SL → Nifedipine    

     Accessories reinforcing material:PEG

    2. Cris-PEG → Griseofulvin  

     Accessories reinforcing material:PEG

    3. Kaletra   → Lopinavir / ritonavir

     Accessories reinforcing materialCopovidone

    4. Rezulin   → Troglitazone

     Accessories reinforcing materialPovidone

    Hot-melt extruder principle 

    Hot-melt extruder technology  Two or more of the samples were placed in a temperature controlled barreltogether heated to a molten state.Under the action of the screw, the samples were cut, mix, and finally through a die under a certain pressure,become dispersed uniformly shaped product

    l  Hot-melt extruder basic ideaPlace multiple segments threaded element within different functions in the axial space.So that multiple samples size decreases, and mutual penetration and exchangeeventually achieve molecular level mixing

    ATS Industrial Co. Ltd is a professional high pressure homogenizer (high pressure cell crusher) supplier, Switzerland Jetpharma superfine jet mill and other micro processing equipment! Especially high pressure cell crusher is widely used in biological industry!
    Broken pure machinery, in the cooler system, large flow efficiently broken. Is the biotechnology industry of essential production tool!
    ATS is a professional high pressure homogenizer suppliers and service providers;
    ATS Industrial Systems Co., Ltd. was founded in 1998 in BVI, Canada SEEKER industrial company pharmaceutical equipment suppliers;
    In 2000 to open an office in Shanghai, has been committed to the introduction of advanced homogeneous, crushing, emulsion preparation equipment;
    In 2001 ATS Chinese sales in the first high pressure homogenizer;
    2004 is the first one liposome production line to provide high pressure homogenizer;
    In 2006 ATS introduced the homogenizing machine design and technology the most advanced in Europe; the parts of Europe's premier, Shanghai in the development of AH100 series high pressure homogenizer, obtained the customer's wide acclaim!
    In 2006 December established a technical support center in Shanghai.
    Also in 2007 the introduction of the high-pressure homogenization machine series products in AH-PLIOT, at the same time for drug class customers, special requirements and bio pharmaceutical customers, develop high pressure homogenizer specifically with the corresponding!
    Over the years, ATS bearing support and trust of the users; has the firm for the Chinese customers to develop new formulations of the direction of the device, we bear in mind that quality is the life of enterprise, innovation is the pillar; will reward customers with excellent quality and perfect after sale service!
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