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GsMTx4
Place of Origin:
France
Brand:
Smartox
Model:
0.1 mg
Supplier:
Smartox Biotech
Price:
120 €
Hits:
1260 
Updated:
6/18/2014
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  • Product Detail
  • Company Profile
    GsMTx4, Selective blocker of mechanosensitive ion channels GsMTx4 (GsMTx-4, M-theraphotoxin-Gr1a) has been isolated from the venom of the spider Grammostola rosea. This cationic hydrophobic polypeptide blocks selectively the gating of cation selective channels and mechanosensitive ion channels such as TRPC1 or TRPC6, without having any effect on whole-cell voltage-sensitive currents. This toxin acts by perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. GsMTx4 also demonstrated to active TRPA1 channel at 1µM concentration and to inhibit Piezo1 currents. GsMTx4 technical information AA sequence: Gly-Cys2-Leu-Glu-Phe-Trp-Trp-Lys-Cys9-Asn-Pro-Asn-Asp-Asp-Lys-Cys16-Cys17-Arg-Pro-Lys-Leu-Lys-Cys23-Ser-Lys-Leu-Phe-Lys-Leu-Cys30-Asn-Phe-Ser-Phe-NH2 Disulfide bonds: Cys2-Cys17, Cys9-Cys23 and Cys16-Cys30 Length (AA): 34 Formula: C185H273N49O45S6 Molecular Weight: 4095.2 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: Source: Synthetic Purity rate: > 97 % http://www.smartox-biotech.com/en/other-targets/179-gsmtx4
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
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