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Huwentoxin-I
Place of Origin:
France
Brand:
Smartox
Model:
0.1 mg
Supplier:
Smartox Biotech
Price:
200 €
Hits:
1119 
Updated:
6/18/2014
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  • Product Detail
  • Company Profile
    Huwentoxin-I, Blocker of N-type Ca2+ channel and TTX-S channels Huwentoxin-I (HwTx-I) is a neurotoxin that was originally isolated from the venom of the Chinese bird spider Ornithoctonus huwena. Huwentoxin-I is known to be an inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels (TTX-S) (IC50 ~ 50 nM) and N-type voltage-sensitive calcium channels (IC50 ~ 100 nM) in mammalian DRG, hippocampus and insect's DUM neurons. It has only a very weak effect on L-type calcium channels, no effect on TTX-R channels and has virtually no effect on muscle sodium channels. The selectivity of Huwentoxin-I for calcium channels appears to be higher than ω-conotoxin MVIIA and equivalent to ω-conotoxin GVIA. Huwentoxin-I demonstrated an antinociceptive effect in the rat model of the formalin test when administrated intrathecally (ED50 ~ 0.28 µg/kg), without side effects of the ones led by ω-conotoxin MVIIA. Huwentoxin-I technical information AA sequence: Ala-Cys2-Lys-Gly-Val-Phe-Asp-Ala-Cys9-Thr-Pro-Gly-Lys-Asn-Glu-Cys16-Cys17-Pro-Asn-Arg-Val-Cys22-Ser-Asp-Lys-His-Lys-Trp-Cys26-Lys-Trp-Lys-Leu-OH Disulfide bonds: Cys2-Cys17, Cys9-Cys22 and Cys16-Cys29 Length (aa): 33 Formula: C168H250N46O41S6 Molecular Weight: 3751.77 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: Source: Synthetic Purity rate: > 97 % http://www.smartox-biotech.com/en/calcium-channel/105-huwentoxin-i
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
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