Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 200 pM and Kv1.1 with an IC50 value of around 140 pM. This peptide toxin was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.
Agitoxin-2 technical information
AA sequence: Gly-Val-Pro-Ile-Asn-Val-Ser-Cys8-Thr-Gly-Ser-Pro-Gln-Cys14-Ile-Lys-Pro-Cys18-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys28-Met-Asn-Arg-Lys-Cys33-His-Cys35-Thr-Pro-Lys-OH
Disulfide bonds: Cys8-Cys28; Cys14-Cys33; Cys18-Cys35
Length (aa): 38
Formula: C169H278N54O48S8
Molecular Weight: 4090.89 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 168147-41-9
Source: Synthetic
Purity rate: > 97 %
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Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.