We know that the needs in early development are different from the needs in late development and we tailor our approach based on information from the client and our experience with a wide range of compounds. At Crystal Pharmatech, we utilize a unique screening approach that combines the speed of automated screening with the quality of manual screening. Our scientists will provide a screen that is on scale with your early or late stage compound. The information obtained can be used to select a form, help develop or modify existing crystallization and formulation processes, or provide intellectual property.
Benefits of our solid form screening and selection services include:
1.Polymorph/Salt/Cocrystal Screening
• Improving physical properties such as stability, hygroscopicity, and melting point
• Increasing bioavailability for weak acids and bases or neutral compounds
2.Amorphous Solid Dispersion Screening
• Improving the absorption of poorly soluble drugs by developing dispersion formulations
• Identifying key risks, such as chemical and physical stability, of resulting dispersions
• Evaluating dispersions in early and late phase formulations
3.Thermodynamic Form Relationship
• Determining the thermodynamically stable form
• Providing a thorough understanding of the thermodynamic relationships among the relevant solid phases of your API
• Defining the critical controls and conditions to prevent conversion of the desired form
4.Solid Form Evaluation and Selection
• Collecting the right information on relevant solid forms for direct comparison
• Recommending the best solid form based on the properties of the material and your development plan
• Providing ideas on alternative forms and formulations for long term strategic considerations
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