Crystallization is a critical unit operation in API manufacturing. Desired product quality attributes can be obtained economically with high efficiency through well-designed and controlled crystallization processes. Successful crystallization development is based on a fundamental understanding of physicochemical and engineering principles, implementation and development of technologies and expertise in specialized areas. |
Purification
Crystallization is the most effective method to purify a chemical compound at industrial scale. A well-designed and controlled crystallization process >>
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Process Optimization
Meeting delivery deadlines often takes higher priority than process optimization. As a drug candidate moves forward in development >>
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Polymorphic Isolation
For a drug substance, a certain solid form is often desired for proper dissolution or bioavailability, stability, processing or intellectual property. >>
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Technology Application
One of the highlights of our crystallization development is effective implementation of available and new technologies. In addition to our rich >>
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Particle Attributes Control
Many attributes of API particles (e.g., size, density, morphology, hydroscopicity, static behavior, etc.) can impact the quality of a final drug product. >>
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Technology Transfer
Seamless transfer of crystallization processes developed at Crystal Pharmatech is ensured based on our experience in successfully >>
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Chiral Separation
More than 70% of drug candidates worldwide are chiral. Typically, for chiral API, only one stereoisomer is biologically active. >>
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