Sepax has developed proprietary process for separation and purification of complex pharmaceutical mixtures, natural products and biological samples with high speed and in highly economical way. Sepax has accumulated a wide range of expertise and skills in separating and purifying a mixture of a few of compounds to a natural product of more than 500 compounds effectively. The separation and purification covers small molecules to peptides to proteins, such as antibodies.
Uniqueness
- Sepax manufactures more than 200 different separation media, covering silica and polymer materials with particle selection from 1 to 100 µm and pore size selection from 60 to 2000 Å. The chemistry includes reversed phases, normal phases, HILIC, ion-exchange, size exclusion, SFC, affinity and custom-synthesized phases.
- Sepax manufactures preparative separation columns covering flash chromatography to HPLC. The column dimensions are from regular 2 and 3 cm ID to larger ones for process separation.
- Sepax has accumulated a variety of proprietary expertise, techniques, and skills for fast and economical separation and purification processes. Sepax purified more than 35,000 compounds from natural products in 2007.
- Sepax has strong expertise and experts on mass spectrometry analysis to further test the purified compounds.
Facilities for Separation and Purification
- More than 20 HPLC equipments
- 3 Mass Spectrometers
- Bulk separation media and columns manufactured in house
- Lyophilization equipments
- 10,000 ft² lab space and 50,000 ft² lab space is under construction
Separation and Purification Areas
- Pharmaceutical and neutraceuticals
- Natural products and traditional Chinese medicine
- Peptides
- Proteins, e.g. antibodies and enzymes
- Oligonucleotides and DNA
- Nanomaterials, e.g. nanoparticles, carbon nanotubes
- Cell lysates
Methods
- Extraction
- Flash Chromatography
- Thin layer chromatography
- HPLC separation
- Preparative LC separation
Characterization & Identification
- LC chromatography
- UV-vis
- LC/MS
- NMR
Example - Natural Product Separation
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