Production-Scale High Pressure Homogenizer,Shanghai Duoning Biotechnology_specification/price/image

Product Detail
Company Profile

1.Details

High-pressure homogenizer is a critical piece of equipment that utilizes ultra-high pressure to force materials through narrow gaps at high velocity, creating physical effects such as shear, impact, and cavitation. This enables cell disruption, particle size reduction, and fluid homogenization. Key operational parameters include homogenization pressure, number of passes, and processing temperature, all of which can be flexibly adjusted according to process requirements.

In the biopharmaceutical industry, high-pressure homogenizers are widely used for cell disruption and extraction in E. coli, yeast, and mammalian cells; the preparation of recombinant proteins and vaccine antigens; and the homogenization of nanoparticles. By optimizing process conditions, high-pressure homogenization can achieve efficient and highly reproducible processing while maintaining the integrity of active products.

Duoning Biotech’s high-pressure homogenizers are specially engineered for bioprocess optimization, offering outstanding cell disruption efficiency and precise particle size control. The equipment covers the full spectrum from lab-scale development to industrial-scale production. Large-scale systems can be equipped with intelligent control software for parameter recording and traceability, ensuring batch-to-batch consistency and process stability. The structural design of Duoning’s homogenizer series emphasizes durability and ease of maintenance, providing robust support to enhance process efficiency and accelerate R&D and time-to-market for customers.

Production-Scale High-Pressure Homogenizers

The industrial-grade high-pressure homogenizer series is designed for applications ranging from large-scale pilot to GMP production. With a single-unit flow rate of up to 600 L/h, it is suitable for a wide variety of processes including recombinant protein production, vaccines, and synthetic biology.

These systems are built to withstand design pressures up to 1600 bar and operate at working pressures up to 1500 bar. Equipped with a robust three-plunger system, they ensure stable and efficient performance. The product line includes a standard base model as well as a GMP-compliant automated version. The GMP version features a 13.3-inch touchscreen, industrial PC, data export capabilities, and audit trail functions to meet regulatory and validation requirements—empowering biopharmaceutical manufacturers to advance toward intelligent, high-end production.


DH12-150	DH22-100/DH22-150	DH37-150

2.Advantages

Available in multiple specifications ranging from 10–600 L/H, flexibly adapting to different process scale requirements
Working pressure up to 1500 bar, suitable for high-shear homogenization scenarios
GMP version equipped with audit trail and data export functions, ensuring regulatory compliance
Zirconia three-plunger structure, stable and durable, supports high-frequency operation
13.3-inch touchscreen + industrial PC, easy operation with a user-friendly interface
Optional external stainless steel heat exchanger to ensure consistent temperature control
Includes a standardized toolkit and seals for convenient maintenance

3.Specification

Duoning Biotech is a leading one-stop bioprocess solutions provider from China, committed to offering products and services required for the discovery, development and commercialization production of biologics, including reagents, consumables, instruments, equipment, and services. Leveraging our integrated bioprocess system, we empower our customers to achieve effective, reliable, lower-cost and higher-quality biologics manufacturing processes.