Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	IL6RA，IL6RQ，IL6Q，Interleukin-6 Receptor alpha Subunit，sIL6R，gp80，IL-6R subunit alpha，Membrane glycoprotein 80，IL6R，Interleukin 6 Receptor，IL-6 Receptor Subunit Alpha，CD126 Antigen，IL-6R 1，IL-6RA，Interleukin-6 Receptor Subunit Alpha，IL-6R-Alpha，IL-6R-1，CD126
Accession	P08887-1
Amino Acid Sequence	Leu20-Pro365 with Human IgG1 Fc & Avi Tag at C-Terminus
Expression System	HEK293
Molecular Weight	72-95kDa (Reducing)
Purity	> 95 % as determined by SDS-PAGE & SEC-HPLC
Endotoxin	<1EU/μg
Conjugation	Biotin
Tag	Avi Tag, Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.M Hibi, M Murakami, M Saito, T Hirano, T Taga, TKishimoto. Molecular cloning and expression of an IL-6 signal transducer,gp130.Cell. 1990 Dec 21;63(6):1149-57. 2. Bin S, Xin L, Lin Z, Jinhua Z, Rui G, Xiang Z.Targeting miR-10a-5p/IL-6Raxis for reducing IL-6-induced cartilage cell ferroptosis.Exp Mol Pathol. 2021Feb;118:104570. Cell., 63 (1990), pp. 1149-1157.

Background

The interleukin-6 receptor (IL-6R) comprises an 80-kDa IL-6-binding protein (α chain/CD126) and gp130. CD126, a glycoprotein with the ligand-binding site, is part of the human IL-6R, which spans 468 amino acids, including a signal peptide, extracellular region, transmembrane domain, and a short cytoplasmic domain of 19, 339, 28, and 82 amino acids, respectively. IL-6R is present on multiple myeloma, hepatocellular carcinoma, prostate carcinoma, and epidermoid carcinoma cells. The IL-6/IL-6R pathway drives tumor growth, particularly in gliomas, making IL-6R a drug delivery target and a therapeutic target. Primary human cartilage cells express IL-6R, which is upregulated by IL-6, positioning cartilage cells as direct targets of IL-6.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.