VAV1 GST Tag Protein, Human,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	VAV1
Accession	P15498-1
Concentration	1mg/ml by Nanodrop
Amino Acid Sequence	Lys782-Cys845, with GST tag at N-terminal
Expression System	E.coli
Molecular Weight	33-43kDa (Reducing)
Purity	＞90% by SDS-PAGE & SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	GST Tag
Physical Appearance	Liquid
Storage Buffer	50 mM Tris, 150 mM NaCl, 1 mM DTT, 10% glycerol, pH7.5
Stability & Storage	·Stable for 12 months upon stored at -80℃ from the date of receipt. And avoid repeated freeze-thaws cycles.
Reference	1. Chrencik J E, Brooun A, Zhang H, et al. Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1[J]. Journal of molecular biology, 2008, 380(5): 828-843.

Background

Vav1 Guanine Nucleotide Exchange Factor (VAV1) is a member of the VAV gene family and is exclusively expressed in the hematopoietic system. It functions as a GDP/GTP nucleotide exchange factor (GEF), activating pathways that lead to actin cytoskeletal rearrangements and transcriptional alterations. VAV1 contains several characteristic structural motifs that are crucial for its role as a versatile signal transducer.
VAV1 is essential for hematopoiesis, playing a key role in the development and activation of T cells and B cells. It has also been identified as a specific binding partner for Nef proteins from HIV-1.
Expression of VAV1 is restricted to cells of hematopoietic origin, including those of the erythroid, lymphoid, and myeloid lineages. Diseases associated with VAV1 include cherubism and HIV-1 infection.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.