CD28 Fc Chimera Protein, Human/Cynomolgus/Rhesus macaque,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Cynomolgus
Synonyms	CD28 Antigen，T-Cell-Specific Surface Glycoprotein CD28，CD28 Antigen (Tp44)，Tp44，CD28 Antigens，CD28 Molecule，T-Cell-Specific Surface Glycoprotein
Accession	P10747
Amino Acid Sequence	Asn19-Pro152 with Human IgG1 Fc at C-Terminus
Expression System	HEK293
Molecular Weight	50-70kDa (Reducing)
Purity	＞95% by SDS-PAGE & SEC-HPLC
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS PH7.4 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Courtemanche O, Huppé CA, Blais-Lecours P, Maranda C, Morissette MC, Blanchet MR, Dion G, Marsolais D. Ex Vivo Overactivation of Lymphocyte Subsets in Fibrotic Hypersensitivity Pneumonitis Is Blunted by a Sphingosine-1-Phosphate Receptor Ligand. Int J Mol Sci. 2025 Mar 29;26(7):3197.

Background

T-cell-specific surface glycoprotein CD28, also known as TP44, is a single-pass type I membrane protein containing one Ig-like V-type (immunoglobulin-like) domain. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals required for T cell activation. It serves as the receptor for CD80 (B7.1) and CD86 (B7.2). When antigen-presenting cells (APCs) are activated by Toll-like receptor ligands, CD80 expression is upregulated. In contrast, CD86 expression on APCs is constitutive. Notably, CD28 is the only B7 receptor constitutively expressed on naive T cells, highlighting its crucial role in the initial activation of T cells.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.