ADORA2A (wild type) His-Flag-Twinstrep Tag Protein, Human (Detergent),UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	ADORA2A, adenosine A2a receptor, A2aR, ADORA2, RDC8
Accession	P29274
Concentration	1mg/ml by Nanodrop
Amino Acid Sequence	Full length (wt), and Flag tag at N-Terminal, and His-Twinstrep tag at C-Terminal
Expression System	CHO
Molecular Weight	52.7 kDa
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag, Strep Tag
Physical Appearance	Liquid
Storage Buffer	20 mM Hepes, pH 8.0, 100 mM NaCl, 0.05 % DDM, 0.01 % CHS
Stability & Storage	·6 months from date of receipt, -60 to -80 °C as supplied. ·about 3 days in 2 to 8 °C. ·Please avoid repeated freeze-thaw cycles.
Reference	1. Lebon G, Warne T, Edwards P C, et al. Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation[J]. Nature, 2011, 474(7352): 521-525.

Background

The Adenosine Receptor A2AR (ADORA2A) is a member of the G protein-coupled receptor (GPCR) superfamily. GPCRs are seven-transmembrane proteins that transduce extracellular signals into intracellular responses. A2AR binds adenosine as its endogenous agonist and interacts with Gs and Golf proteins to increase intracellular cAMP levels. This receptor plays crucial roles in cardiac rhythm, cerebral and renal blood flow, immune function, pain modulation, and sleep regulation. It is also associated with pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. The A2AR receptor is a key player in multiple physiological processes and holds significant potential as a therapeutic target. The A2AR protein product may enhance drug discovery efforts.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.