IL-21R Fc Chimera Protein, Human,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	CD360, NILR
Accession	Q9HBE5-1
Amino Acid Sequence	Cys20-Pro236 with hIgG1 Fc at the C-terminus
Expression System	HEK293
Molecular Weight	65-75kDa (Reducing)
Purity	＞95% by SDS-PAGE & ＞90% by SEC-HPLC
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS PH7.4 , 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Ren Y, Xue M, Hui X, Liu X, Farooq MA, Chen Y, Ji Y, Duan Y, Ajmal I, Yao J, Jiang W. Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer. Pharmacol Res. 2025 Feb;212:107637.

Background

Human interleukin-21 receptor (IL21R), also known as CD360 or NILR, is a type I cytokine receptor belonging to the type 4 subfamily. It contains two fibronectin type-III domains and is selectively expressed in lymphoid tissues, with the highest expression in the thymus and spleen. IL21R is crucial for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells, as it transduces the growth-promoting signals of interleukin-21 (IL-21).

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.