IL-18Rβ/IL-1R7 Fc Chimera Protein, Human,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	Accessory protein-like; AcPL; CD218 antigen-like family member B; CD218b antigen; CD218b; CDw218b; IL-1 R7; IL-18 R beta; IL-18 receptor accessory protein; IL-18 receptor beta; IL18R beta; IL-18RAcP; IL18RAP; IL18RB; IL-18Rb; IL-18Rbeta; IL-18R-beta; IL-1R accessory protein-like; IL1R7; IL-1R7; IL-1R-7; IL-1RAcPL; interleukin 18 receptor accessory protein; Interleukin-1 receptor 7; interleukin-18 receptor accessory protein; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta; MGC120589; MGC120590
Accession	O95256
Amino Acid Sequence	Phe20-Arg356 with Human IgG1 Fc at C-Terminus
Expression System	HEK293
Molecular Weight	72-95kDa (Reducing)
Purity	>95% by SDS-PAGE & SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4,5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Parnet, P. et al. (1996) J. Biol. Chem. 271:3967.

Background

Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immunoregulatory functions with IL-12. The functional IL-18 receptor complex consists of two subunits: IL-18Rα (also known as IL-1R5 or IL-1Rrp) and IL-18Rβ (also known as IL-1R7 or AcPL). Both subunits belong to the IL-1 receptor superfamily. IL-18R is widely expressed in various tissues, including the spleen, thymus, leukocytes, liver, lung, heart, small and large intestines, prostate, and placenta.
The IL-18 receptor complex is responsible for binding the pro-inflammatory cytokine IL-18, but not IL-1α or IL-1β. It is involved in IL-18-mediated IFNγ synthesis from T-helper 1 (Th1) cells and contributes to IL-18-induced cytokine production, either independently of SLC12A3 or as a complex with SLC12A3.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.