TIM1/HAVCR1 His Tag Protein, Human,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	CD365; HAVCR1; HAVCR-1; HAVCRT cell immunoglobin domain and mucin domain protein 1; hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM1; KIM-1; T-cell immunoglobulin and mucin domain-containing protein 1; TIM1; TIM-1; TIM-1TIM; TIM1TIMD-1; TIMD1T-cell membrane protein 1
Accession	Q96D42
Amino Acid Sequence	Ser21-Gly295 with His Tag at C-Terminus
Expression System	HEK293
Molecular Weight	72-95kDa (Reducing)
Purity	> 95% by SDS-PAGE & SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, 5% trehalose, PH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Meyers, J.H. et al. (2005) Trends Mol. Med. 11:1471. 2.Kuchroo, V.K. et al. (2003) Nat. Rev. Immunol. 3:454. 3.Mariat, C. et al. (2005) Phil. Trans. R. Soc. B 360:1681.

Background

HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) or T cell immunoglobulin mucin 1 (TIM-1), is an integral membrane glycoprotein. KIM-1 is widely expressed, with the highest levels found in the kidney and testis. It is recognized as a major susceptibility gene for asthma, allergy, and autoimmunity in humans. IgA1lambda, a specific ligand of KIM-1, has been shown to have a synergistic effect in virus-receptor interactions. KIM-1 is implicated in the pathogenesis of acute kidney injury and has been confirmed as a biomarker of renal dysfunction in human urine. Additionally, KIM-1 is a novel regulatory molecule of flow-induced calcium signaling

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.