LDLR His Tag Protein, Cynomolgus,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Cynomolgus
Synonyms	FH, FHC, LDLCQ2
Accession	XP_005588053.2
Amino Acid Sequence	Ala22-Gly788 with His tag at the C-Terminus
Expression System	HEK293
Molecular Weight	120-140kDa (Reducing)
Purity	＞95% by SDS-PAGE & SEC-HPLC
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Canbay E, Canda E, Yazıcı H, Kasıkcı GK, Durmaz B, Copur O, Tahhan B, Düzgün D, Koru ZE, Sezer E, Aydın D, Levent RE, Ucar SK, Coker M, Sozmen EY. Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia. Lipids Health Dis. 2024 Nov 13;23(1):374.

Background

The Low-Density Lipoprotein (LDL) Receptor, also known as LDLR, FH, FHC, or LDLCQ2, is a mosaic protein composed of approximately 840 amino acids (after signal peptide removal) that mediates the endocytosis of cholesterol-rich LDL. This cell-surface receptor recognizes apolipoprotein B100, which is embedded in the phospholipid outer layer of LDL particles, as well as apolipoprotein E found in chylomicron remnants and VLDL remnants (IDL). The LDL receptor belongs to the LDL receptor gene family.
LDL receptor complexes are located in clathrin-coated pits on the cell surface. When bound to LDL-cholesterol via adaptors, these complexes are internalized to form clathrin-coated vesicles within the cell. This process, known as endocytosis, allows for the efficient internalization of LDL-cholesterol and prevents it from diffusing across the membrane surface. This occurs in all nucleated cells, but is most prominent in the liver, which removes approximately 70% of LDL from the circulation.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.