HGFR/c-MET Fc Chimera Protein, Human,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	HGFR, c-MET, HGF/SF receptor, DFNB97, AUTS9, RCCP2, Hepatocyte growth factor receptor, Tyrosine-protein kinase Met
Accession	P08581
Amino Acid Sequence	Glu25-Thr932 with Human IgG1 Fc at C-Terminus
Expression System	HEK293
Molecular Weight	34-48 kDa and 105-125 kDa (Reducing)
Purity	> 95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Neculai D. et al. (2013) Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature. 504: 172-176. McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73. Garcia S. et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-335. Socoteanu M P. et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-2994. Kong D S. et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.

Background

HGF R, also known as Met, is a glycosylated receptor tyrosine kinase that plays a pivotal role in epithelial morphogenesis and cancer development. It is synthesized as a single-chain precursor, which undergoes cotranslational proteolytic cleavage to form a mature HGFR. This mature receptor is a disulfide-linked dimer consisting of a 50 kDa extracellular alpha chain and a 145 kDa transmembrane beta chain. The extracellular domain (ECD) features a seven-bladed beta-propeller sema domain, a cysteine-rich PSI/MRS domain, and four Ig-like E-set domains. The cytoplasmic region contains the tyrosine kinase domain. HGFR is typically expressed by cells of epithelial origin, while HGF expression is limited to cells of mesenchymal origin.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.