Biotinylated PSMA/FOLH1 His & Avi Tag Protein, Cynomolgus,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Cynomolgus
Synonyms	FOLH1, PSMA, GIG27, FOLH, NAALAD1, PSM, NAALADase I, GCPII, FGCP
Accession	A0A2K5VNZ0
Amino Acid Sequence	Lys44-Ala750 with His Tag & Avi Tag at N-Terminus
Expression System	HEK293
Molecular Weight	95-110kDa (Reducing)
Purity	＞95% by SDS-PAGE
Conjugation	Biotin
Tag	Avi Tag, His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Chen L, Cheng S, Zhu D, Bao G, Wang Z, Deng X, Liu X, Ma X, Zhao J, Zhu L, Zhu X. Synthesis and Preclinical Evaluation of Dual-Specific Probe Targeting Glypican-3 and Prostate-Specific Membrane Antigen for Hepatocellular Carcinoma PET Imaging. Mol Pharm. 2024 Dec 10.

Background

Prostate-specific membrane antigen (PSMA), also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), or N-acetylated-alpha-linked acidic dipeptidase I (ALAD1), is a member of the peptidase M28 family and M28B subfamily. PSMA is stable at pH levels greater than 6.5 and is a type II transmembrane zinc metallopeptidase with high expression in the nervous system, prostate, kidney, and small intestine.
PSMA forms homodimers, binds two zinc ions per subunit, and is required for its ALADase activity. It exhibits catalytic activity involved in the release of an unsubstituted, C-terminal glutamyl residue, typically from sequences such as Ac-Asp-Glu or folylpoly-gamma-glutamates. PSMA possesses both folate hydrolase and N-acetylated-alpha-linked acidic dipeptidase (ALADase) activities, showing a preference for tri-alpha-glutamate peptides.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.