Serpin G1/C1 Inhibitor His Tag Protein, Human,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	SERPING1, C1IN, C1-INH, C1IN, HAE1, HAE2
Accession	P05155-1
Amino Acid Sequence	Asn23-Ala500 with His Tag at C-Terminus
Expression System	HEK293
Molecular Weight	85-100kDa (Reducing)
Purity	＞95% by SDS-PAGE &＞90% by SEC-HPLC
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Mahajan SD, Aalinkeel R, Reynolds JL, Machhar JS, Ghebrehiwet B, Schwartz SA. Omics analysis reveals galectin-3 to be a potential key regulator of allergic inflammation in hereditary angioedema. J Allergy Clin Immunol Glob. 2024 Oct 18;4(1):100353. Akeret K, Thomson BR, Ghosh S, Nolte M, Fischer U, Humar R, Regli L, Schaer DJ, Hugelshofer M, Buzzi RM. C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury. Fluids Barriers CNS. 2024 Nov 15;21(1):91.

Background

Serpin G1, also known as C1-inhibitor (C1-INH), is a crucial regulator of the complement, coagulation, fibrinolytic, and contact systems. The levels of protease/C1-INH complexes in the blood correlate with the in vivo activation of these four cascade-like plasma enzyme systems. C1-INH inhibits the activated forms of C1r and C1s, which are part of the first complement component, thereby regulating complement activation. Synthesized in the liver, deficiencies in C1-INH are associated with hereditary angioneurotic edema (HANE).

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.