EDNRB Flag-His Tag full length Protein, Human(Detergent),UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	Endothelin receptor type B, EDNRB, ABCDS, HSCR, HSCR2, ET-B, ET-BR, ETB1, ETBR, ETRB, WS4A
Accession	P24530
Concentration	0.82mg/ml by Nanodrop
Amino Acid Sequence	Wild type full length with Flag-His tag at N-Terminus
Expression System	Baculovirus-InsectCells
Molecular Weight	47.0 kDa
Purity	＞90% by SDS-PAGE &＞90% by SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tags & Cleavage sites	No
Tag	His Tag, Flag Tag
Storage Buffer	10 mM Hepes, pH 7.5, 200 mM NaCl, 0.01 % LMNG, 0.001 % CHS.
Stability & Storage	·6 months from date of receipt, -60 to -80 °C as supplied. ·about 3 days in 2 to 8 °C. ·Please avoid repeated freeze-thaw cycles.
Reference	1. Ji, Yujie, et al. "Structural basis of peptide recognition and activation of endothelin receptors." Nature Communications 14.1 (2023): 1268.

Background

Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor, which the activity and function was regulated by G proteins that activate a phosphatidylinositol-calcium second messenger system. The EDNRB membrane protein is widely located in the human body, which involved in the regulation of many physiological activities, such as binding to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum. Endothelin performs its biological function by its receptor (ETR), such as EDNRB. Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors, which can promote tumor growth and metastasis, and can promote anti-apoptosis and angiogenesis.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.